Microplastic has been discovered as a new pollutant recently and ruined the ecological environment ubiquitously and pervasively to endanger the health and life of all global creatures. Nevertheless, humans don't notice such a dangerous situation. Therefore, this up-to-dated socio-scientific issue is worth exploring and searching solutions. The topic of this study is based on the ＂Microplastic＂ issue, which is applying Socio-Scientific Issue (SSI) model, teaching involved with technology issue in the new curriculum guideline, developing the Problem-based learning (PBL) to flourish students' problem-solving abilities. Specifically, the study aims to help students to construct the relative knowledge of microplastic and problem-solving ability and propose specific solving strategies to fulfill the environment protection to microplastic.